|
KMID : 0861020100250010039
|
|
Korea Journal of Herbology
2010 Volume.25 No. 1 p.39 ~ p.43
|
|
|
Anticoagulant Activity of Gleditsiae Spina Extract
|
|
Yoo Ji-Hyun
Jung Bung-Tea
Kil Ki-Jung
|
|
|
Abstract
|
|
|
Objectives: This research was investigated the anticoagulant effect of the Gleditsiae spina extract.
Methods: We researched prothrombin time (PT) assay, activated partial thromboplastin time (APTT) assay in vitro and in vivo using arteriovenous (A-V) shunt rat model and shortening Rat tail bleeding time (BT). A-V shunt and BT were treated with extract of Gleditsiae spina (GS) 400 ㎎/kg for a week.
Results: Bleeding time of Gleditsiae spina extract in vivo had a significant increase as about 1.2 times and thrombus weight of Gleditsiae spina extract had a significant reduction of thrombus weight as 26%. Gleditsiae spina extract represented an effect of anticoagulation by operating on extrinsic pathway factor II, V, VII, X and intrinsic pathway factor Ⅷ, Ⅸ, Ⅹ, ?, ? in the coagulation system.
Conclusions: Considering the above mentioned results, it is judged that a Gleditsiae Spina extract has a control effect of thrombus creation.
|
|
|
KEYWORD
|
|
|
Gleditsiae Spina, Anticoagulant, Thrombosis, Prothrombin time, Bleeding time
|
|
|
FullTexts / Linksout information
|
|
|
|
|
Listed journal information
|
|
|
|